Xov xwm

Xyoo 1968, Kruger-Theimer tau piav qhia txog yuav siv cov qauv pharmacokinetic li cas los tsim cov kev kho mob kom zoo. Cov kev kho mob Bolus, Elimination, Transfer (BET) no muaj:

ib koob tshuaj bolus uas xam kom puv qhov chaw nruab nrab (ntshav),

kev txhaj tshuaj tas li sib npaug rau qhov nrawm ntawm kev tshem tawm,

ib qho kev txhaj tshuaj uas them rov qab rau kev hloov mus rau cov ntaub so ntswg peripheral: [tus nqi txo qis exponentially]

Kev coj ua ib txwm muaj xws li kev xam cov txheej txheem infusion rau propofol los ntawm txoj kev Roberts. Ib koob tshuaj 1.5 mg/kg loading tom qab ntawd yog 10 mg/kg/teev infusion uas txo qis rau tus nqi ntawm 8 thiab 6 mg/kg/teev ntawm kaum feeb.

Kev tsom mus rau qhov chaw cuam tshuam

Cov teebmeem tseem ceeb ntawmtshuaj loogCov tshuaj uas txhaj rau hauv cov hlab ntsha yog cov tshuaj uas ua rau tsaug zog thiab ua rau lub hlwb tsis ua haujlwm thiab qhov chaw uas cov tshuaj ua rau cov teebmeem no, hu ua qhov chaw ua haujlwm yog lub hlwb. Hmoov tsis zoo nws tsis yooj yim sua kom ntsuas qhov concentration ntawm lub hlwb [qhov chaw ua haujlwm]. Txawm tias peb tuaj yeem ntsuas qhov concentration ntawm lub hlwb ncaj qha los xij, nws yuav tsum paub qhov concentration ntawm thaj chaw lossis txawm tias qhov concentration ntawm cov receptor uas cov tshuaj ua rau nws cov teebmeem.

Ua tiav qhov kev sib xyaw ua ke ntawm propofol tas li

Daim duab hauv qab no qhia txog qhov nrawm ntawm kev txhaj tshuaj uas xav tau ntawm qhov nrawm txo qis tom qab noj tshuaj bolus kom tswj tau qhov concentration ntawm propofol hauv cov ntshav kom ruaj khov. Nws kuj qhia txog qhov ncua sij hawm ntawm cov ntshav thiab qhov concentration ntawm qhov cuam tshuam.